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18 F-FAPI Outperforms 18 F-FDG PET/CT in Detecting Focal Inflammation as a Cause of Refractory In-Stent Restenosis :
Hangyu Xie1, Xu Han1, Hongzhi Mi1
1Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases.
Abstract:
Inflammation-associated coronary artery disease (I-CAD) is a recognized yet underdiagnosed cause of refractory in-stent restenosis. Conventional imaging modalities often lack sensitivity for detecting focal inflammatory activity. A 74-year-old woman with recurrent ISR was admitted to our institution. Dual-tracer ¹⁸F-FAPI and ¹⁸F-FDG PET/CT revealed locally increased radiotracer uptake within the left anterior descending artery (LAD) stent segment, with more intense uptake on 18 F-FAPI than on 18 F-FDG. We present the dual-tracer PET/CT findings in this patient with recurrent in-stent restenosis, suggesting active peri-stent fibroblast-related remodeling and an inflammation-associated mechanism. The patient was subsequently managed with anti-inflammatory therapy rather than repeated revascularization.
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