Multimodal Imaging Findings in Bilateral Diffuse Uveal Melanocytic Proliferation (BDUMP)

To present a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), which is a rare paraneoplastic syndrome that causes progressive visual loss in patients with an underlying malignancy.

A 59-year-old female patient presented with bilateral visual loss, which had started three months earlier. She had a history of treated ovarian cancer a year before. Fundus examination showed multiple red-orange subretinal patches with irregular and elevated pigmented tumors in both eyes, scattered over the fundus. Multimodal imaging was also consistent with BDUMP. She was referred to a clinical oncologist and underwent screening for systemic metastasis, which revealed multiple foci of secondary malignancies.

Ophthalmologists should be aware of this extremely rare condition. Although there is currently no effective treatment for ocular symptoms, the patient should be promptly referred to an oncologist for systemic screening and potential treatment of the primary site malignancy.