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Disseminated Intravascular Coagulation and Advances in D-Dimer Testing: Progress in Harmonization of Clinical Assays
Ecaterina Scarlatescu1, Cheryl L Maier2, Jerrold H Levy3
1"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania; Department of Anaesthesia and Intensive Care, Fundeni Clinical Institute, Bucharest, Romania.
Abstract:
The measurement of D-dimer, a fibrin degradation product, has become integral to diagnosing and managing thrombotic disorders, particularly disseminated intravascular coagulation. This report synthesizes current knowledge on D-dimer biochemistry, assay methodologies, clinical utility, and ongoing challenges in standardization. By analyzing recent advancements in harmonization efforts and innovative detection technologies, this review highlights the critical role of D-dimer in coagulation diagnostics while addressing persistent limitations in specificity and assay variability. Emerging techniques, such as mass-spectrometry and aptamer-based sensors, demonstrate promise for overcoming current barriers, though widespread clinical adoption requires further validation.
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