Novel Clinical and Laboratory Correlations for Antiphospholipid Syndrome

The diagnosis of antiphospholipid syndrome remains a challenge. The 2023 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria improve sensitivity and specificity; it does not, however, surpass clinical judgment. The titers and positivity of antiphospholipid antibodies may change over time, depending on the clinical manifestation and during the acute event. Multiple studies have identified novel laboratory correlations that are associated with different clinical manifestations, risk of complications, and as potential biomarkers in the follow-up of the disease. This review explores the different assays that could be useful for the diagnosis and prognosis of this disease.