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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

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Entrapment Neuropathies.

Ryan Castoro¹, W David Arnold¹

¹Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA; NextGen Precision Health, University of Missouri, Columbia, USA.

Neurologic Clinics

|October 29, 2025

Summary

This summary is machine-generated.

Peripheral nerve entrapment and impingement neuropathies cause nerve damage. This review covers common conditions like carpal tunnel syndrome, their causes, symptoms, and treatments.

Keywords:

Carpal tunnel syndrome Median neuropathy Radial neuropathy Ulnar neuropathy

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Area of Science:

Neurology
Clinical Medicine
Peripheral Nerve Disorders

Background:

Entrapment and impingement neuropathies involve peripheral nerve compression or irritation.
These conditions result in sensory and motor deficits affecting a single nerve.

Purpose of the Study:

To review the pathophysiology, clinical presentations, and evidence-based management of common entrapment neuropathies.
To discuss less common nerve impingement disorders, their clinical relevance, and diagnostic difficulties.
To explore the association between systemic diseases and entrapment neuropathies.

Main Methods:

Literature review of pathophysiology, clinical presentations, and management strategies.
Discussion of common and less common nerve entrapment syndromes.
Exploration of systemic disease associations.

Main Results:

Detailed discussion of carpal tunnel syndrome, ulnar neuropathy at the elbow, fibular neuropathy, radial nerve entrapment, and lateral femoral cutaneous nerve entrapment.
Highlights clinical relevance and diagnostic challenges of less common neuropathies.
Examines systemic diseases frequently associated with entrapment neuropathies.

Conclusions:

Comprehensive understanding of entrapment neuropathies is crucial for accurate diagnosis and effective management.
Timely identification and treatment can mitigate sensory and motor deficits.
Awareness of systemic associations aids in holistic patient care.