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Photodynamic Therapy versus Surgery in Management of Oral Squamous Cell Carcinoma: A Comparative Study
Debajyoti Bardhan1, Digvijaysinh Parmar2, Amartya Prakash Srivastava3
1Department of Oral Medicine and Radiology, Hi-Tech Dental College and Hospital, Bhubaneswar, Odisha, India.
Introduction:
"Oral squamous cell carcinoma (OSCC)" is one of the most common malignancies of the oral cavity, often requiring aggressive surgical intervention. "Photodynamic therapy (PDT)" has emerged as a minimally invasive treatment option to enhance the efficacy of surgical treatments. The combination of PDT with surgery has been suggested to reduce recurrence rates and improve overall outcomes.
Methods:
This research aims to evaluate the efficacy of PDT as an adjunct to surgery in treating OSCC, using three key parameters: tumor recurrence rates, survival outcomes, and postoperative complications. A cohort of OSCC patients treated with surgery alone was compared with a cohort treated with both surgery and PDT.
Results:
Patients treated with surgery and PDT demonstrated significantly lower tumor recurrence rates (P < 0.05) and improved 3-year survival outcomes (P < 0.01) compared to surgery alone. Postoperative complication rates did not differ significantly between the two groups (P > 0.05).
Conclusion:
PDT as an adjunct to surgery shows promise in improving recurrence rates and survival outcomes in OSCC without increasing postoperative complications. Further large-scale studies are needed to confirm these findings.
