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A Comprehensive Review of Trigeminal Autonomic Cephalalgias
David McClendon1, Ronald G Riechers2
1Resident, Department of Neurology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
Physical Medicine and Rehabilitation Clinics of North America
|October 30, 2025
Summary
Trigeminal autonomic cephalalgias (TACs) are severe headaches with distinct subtypes. Early diagnosis of these primary headache disorders is crucial for effective, targeted treatments that improve quality of life.
Area of Science:
- Neurology
- Headache Medicine
Background:
- Trigeminal autonomic cephalalgias (TACs) are primary headache disorders.
- TACs present with unilateral head pain and autonomic symptoms like tearing and ptosis.
Purpose of the Study:
- To provide a comprehensive review of TAC subtypes.
- To highlight clinical features and treatment responses for each subtype.
Main Methods:
- Literature review of trigeminal autonomic cephalalgias.
- Analysis of clinical features and treatment outcomes for TACs.
Main Results:
- Detailed description of cluster headache, SUNCT/SUNA, paroxysmal hemicrania, and hemicrania continua.
- Emphasis on distinct clinical presentations and differential diagnoses within TACs.
Conclusions:
- Early recognition and accurate diagnosis of TACs are essential.
- Targeted therapies based on correct diagnosis significantly improve patient outcomes and quality of life.
Keywords:
Cluster headacheHemicrania continuaParoxysmal hemicraniaSUNASUNCTTrigeminal autonomic cephalalgiaMore Related Videos
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