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A Comprehensive Approach to the Assessment and Management of Posttraumatic Headache
1MossRehab Institute for Brain Health, Jefferson Moss Magee Rehabilitation; Department of Rehabilitation Medicine, Sidney Kimmel Medical College.
Physical Medicine and Rehabilitation Clinics of North America
|October 30, 2025
Summary
Posttraumatic headache (PTH) following mild traumatic brain injury (mTBI) is common and difficult to treat. Current treatments lack strong evidence, suggesting a need for a multidisciplinary approach.
Area of Science:
- Neurology
- Trauma Care
- Pain Management
Background:
- Posttraumatic headache (PTH) is a frequent consequence of mild traumatic brain injury (mTBI).
- PTH often presents similarly to migraine or tension-type headaches but is a distinct clinical entity.
- Persistent PTH risk increases with co-occurring mTBI symptoms, postconcussive symptoms, and comorbidities.
Purpose of the Study:
- To review the existing evidence for pharmacologic and nonpharmacologic treatments for PTH.
- To propose a multidisciplinary treatment strategy for PTH based on mTBI management principles.
Main Methods:
- Literature review of current evidence for PTH treatments.
- Analysis of pharmacologic and nonpharmacologic interventions.
- Synthesis of findings to propose a treatment framework.
Main Results:
- Current pharmacologic management of PTH is primarily guided by headache phenotype, lacking robust research support.
- Evidence for nonpharmacologic interventions is also limited but growing.
- A significant gap exists in high-quality research for effective PTH treatments.
Conclusions:
- A multidisciplinary approach, integrating mTBI principles, is recommended for managing PTH.
- Further high-quality research is essential to guide evidence-based pharmacologic and nonpharmacologic treatments for PTH.
- Tailoring treatment to individual patient needs and co-occurring conditions is crucial.

