Balloon Uncrossable Left Main Coronary Artery Dissection: A Case Report and Literature Review

Syed Yaseen Naqvi1,2, Ahmed Qasim Alhaideri3, Ali Razzaq3

  • 1Department of Internal Medicine, College of Medicine University of Warith Al-Anbiyaa Karbala Iraq.

Clinical Case Reports
|October 31, 2025
PubMed

Insights

Managing severe calcified coronary artery disease is challenging. This case demonstrates a novel technique to successfully cross a balloon-uncrossable lesion and treat a dissection during percutaneous coronary intervention.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Vascular Medicine

Background:

  • Coronary artery dissection is a high-risk complication during percutaneous coronary intervention (PCI).
  • Severe calcification significantly increases the complexity and risk of PCI, often leading to undilatable or uncrossable lesions.
  • Left main coronary artery (LMCA) involvement adds further complexity and risk.

Purpose of the Study:

  • To report a novel strategy for managing a balloon-uncrossable, calcified lesion in the left anterior descending (LAD) artery extending into the LMCA.
  • To describe the successful treatment of a large LMCA-to-LAD dissection flap that occurred during PCI.
  • To highlight the importance of innovative approaches and multidisciplinary collaboration in complex coronary interventions.

Main Methods:

  • Percutaneous coronary intervention (PCI) was performed for a calcified ostial-to-mid LAD lesion extending into the LMCA.
  • Initial attempts at balloon pre-dilatation were successful, but a drug-eluting stent (DES) could not cross the lesion.
  • A novel technique involving forceful advancement of a small semi-compliant balloon (1.0 mm) during deflation was used to cross the lesion.
  • Lesion preparation, overlapping DES deployment, and post-dilatation were performed.

Main Results:

  • The novel balloon technique successfully enabled device passage across the previously uncrossable calcified lesion.
  • A large LMCA-to-LAD dissection flap was successfully managed.
  • Overlapping drug-eluting stents were deployed, and post-dilatation resulted in excellent angiographic outcomes.
  • The patient remained hemodynamically stable throughout the procedure.

Conclusions:

  • Complex calcified coronary lesions, especially those extending into the LMCA, pose significant PCI challenges.
  • Innovative techniques, such as using a small semi-compliant balloon during deflation, can overcome device uncrossability.
  • Prompt recognition and management of procedural complications like dissection, coupled with multidisciplinary teamwork, are crucial for successful outcomes in interventional cardiology.