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Scalable Synthesis of a Dual TLR7/8 Agonist via Highly Selective N2-Alkylation of 1H-Pyrazolo[4,3-d]pyrimidine

Kai-Jiong Xiao1, Yingju Xu1, Lu Chen2

  • 1Department of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.

Organic Letters
|October 31, 2025
PubMed

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