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RBFOX2: An RNA-binding protein with alternative splicing and non-alternative splicing regulatory functions
Wei Wang1, Yang Zhang2, Siyi Liu2
1Department of Radiation Oncology, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, China; Cancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, China.
Experimental and Molecular Pathology
|October 31, 2025
Summary
RNA-binding Fox-1 homolog 2 (RBFOX2) is a crucial protein regulating RNA splicing and metabolism. Its dysregulation is linked to various diseases, highlighting its importance in development and physiology.
Area of Science:
- Molecular Biology
- Gene Regulation
- RNA Metabolism
Background:
- RBFOX2 is a key RNA-binding protein controlling alternative splicing.
- It impacts RNA metabolism from transcription through post-transcriptional stages.
- RBFOX2 is regulated by various factors including RNA-binding proteins and non-coding RNAs.
Purpose of the Study:
- To review RBFOX2's regulatory roles in splicing and RNA metabolism.
- To explore upstream factors controlling RBFOX2.
- To elucidate RBFOX2's involvement in disease etiology and progression.
Main Methods:
- Literature review of RBFOX2 functions.
- Analysis of RBFOX2's role in alternative and non-alternative splicing.
- Examination of upstream regulatory mechanisms and disease associations.
Main Results:
- RBFOX2 regulates alternative splicing, RNA epigenetic modifications, transcription, polyadenylation, miRNA processing, and mRNA stability.
- RBFOX2 activity is modulated by RNA-binding proteins, non-coding RNAs, and transcription factors.
- Dysregulation of RBFOX2 is implicated in tumors, cardiovascular, developmental, and metabolic diseases.
Conclusions:
- RBFOX2 plays a vital role in development and physiological homeostasis.
- Understanding RBFOX2 regulation and function offers insights into disease mechanisms.
- Further research on RBFOX2 can pave the way for novel therapeutic strategies.
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