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Updated: Jan 12, 2026

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
Published on: October 13, 2017
Multidisciplinary management of nasal and lacrimal drainage disorders in ectrodactyly-ectodermal dysplasia-clefting
Nandini Bothra1, Lisa Y Lin2, Benjamin S Bleier3
1Govindram Seksaria Institute of Dacryology, L.V Prasad Eye Institute, Hyderabad, Telengana, India.
Insights
Ectrodactyly-ectodermal dysplasia-clefting syndrome (EECS) can cause complex lacrimal drainage issues. A multidisciplinary approach involving oculoplastics and rhinology is crucial for managing these challenging cases.
Area of Science:
- Ophthalmology
- Genetics
- Otorhinolaryngology
Background:
- Ectrodactyly-ectodermal dysplasia-clefting syndrome (EECS) is linked to lacrimal drainage disorders.
- Mutations in the p63 gene are associated with EECS, impacting ectodermal, orofacial, and limb development, and causing developmental delays.
- Complex lacrimal drainage anomalies often necessitate endoscopic surgical approaches.
Abstract:
Ectrodactyly-ectodermal dysplasia-clefting syndrome (EECS) and its association with lacrimal drainage disorders are well known. EECS has p63 gene mutations which affect the ectodermal, orofacial, and limb development along with developmental delay affecting the entire body. Complex lacrimal drainage anomalies typically require endoscopic guidance through the nose for successful outcomes. p63 gene mutations affect the nasal structural development, making the surgical access as well as the outcomes in complex lacrimal drainage disorders difficult to predict and achieve. The present case describes a multidisciplinary approach of the oculoplastic and rhinology services in managing a complex lacrimal drainage disorder.
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