Multidisciplinary management of nasal and lacrimal drainage disorders in ectrodactyly-ectodermal dysplasia-clefting

Nandini Bothra1, Lisa Y Lin2, Benjamin S Bleier3

  • 1Govindram Seksaria Institute of Dacryology, L.V Prasad Eye Institute, Hyderabad, Telengana, India.

Insights

Ectrodactyly-ectodermal dysplasia-clefting syndrome (EECS) can cause complex lacrimal drainage issues. A multidisciplinary approach involving oculoplastics and rhinology is crucial for managing these challenging cases.

Area of Science:

  • Ophthalmology
  • Genetics
  • Otorhinolaryngology

Background:

  • Ectrodactyly-ectodermal dysplasia-clefting syndrome (EECS) is linked to lacrimal drainage disorders.
  • Mutations in the p63 gene are associated with EECS, impacting ectodermal, orofacial, and limb development, and causing developmental delays.
  • Complex lacrimal drainage anomalies often necessitate endoscopic surgical approaches.