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Pharmacologic Profile of A2A Adenosine Receptors: Identifying Patients with Intermittent Claudication and Associated
Pierre Deharo1,2, Julien Fromonot2,3, Soumeya Aliouane1
1Cardiology Department, Timone University Hospital, Marseille, France.
Abstract:
Low-extremity peripheral artery disease (LE-PAD) is often associated with coronary artery disease (CAD). Development of biomarkers is needed to identify those among LE-PAD patients who have associated CAD. The pharmacologic profile of adenosine A2A receptors (A2AR; expression, cyclic adenosine monophosphate [cAMP] production, half maximal effective concentration [EC50]) evaluated on peripheral blood mononuclear cells is useful because these parameters are modified during myocardial ischemia. A total of 127 patients were included; 75 with CAD had a positive flow-fraction-reserve (FFR) but no intermittent claudication. Among those with LE-PAD, 27 had a positive FFR, and 25 had a negative FFR. The A2AR expression and EC50 were lower in patients with a positive FFR vs a negative FFR. Obstructive CAD might be detected by measuring the adenosine A2AR profile.
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