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Updated: Jan 12, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
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Accessing trifluoromethylated SuFEx-able pyrazole via distortion-accelerated 1,3-dipolar cycloadditions

Bipin Khanal1, Mark Aldren M Feliciano2, Brian Gold1

  • 1Department of Chemistry and Biochemistry, New Mexico State University Las Cruces New Mexico 88003 USA bgold@nmsu.edu.

RSC Advances
|November 3, 2025
PubMed
Summary

Researchers synthesized trifluoromethylated pyrazoles using a novel cycloaddition reaction. This method provides a versatile platform for developing new bioactive molecules through efficient chemical diversification.

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