Related Experiment Video
Updated: Jan 6, 2026
05:25
Identification and Protection of the Recurrent Laryngeal Nerve during Transoral Robotic Thyroidectomy
Published on: October 24, 2025
317
Factors Influencing Laryngeal Web After Surgery Combined With Photodynamic Therapy in RRP.
Yufei Pan1,2,3, Huili Huang2,3, Ke Wu2,3
1School of Medicine, Southeast University, Nanjing, Jiangsu, China.
The Laryngoscope
|November 4, 2025
Summary
Laryngeal web (LW) formation after CO2 laser surgery and T-PDT for recurrent respiratory papillomatosis (RRP) is low. Preoperative laryngeal webs increase risk, but bevacizumab treatment may reduce it.
Area of Science:
- Otolaryngology
- Laser Surgery
- Photodynamic Therapy
Background:
- Recurrent respiratory papillomatosis (RRP) is a challenging condition often requiring repeated surgical interventions.
- CO2 laser surgery combined with topical photodynamic therapy (T-PDT) is a treatment modality for RRP.
- Laryngeal web (LW) formation is a potential complication following laryngeal surgery.
Purpose of the Study:
- To identify risk factors for laryngeal web formation after CO2 laser surgery and T-PDT in RRP patients.
- To evaluate the impact of preoperative factors on post-treatment LW development.
Main Methods:
- Retrospective analysis of 86 RRP patients treated with CO2 laser surgery and T-PDT.
- Assessment of laryngeal web severity using the Cohen grading system.
- Multivariate logistic regression to identify independent risk factors for LW formation.
Main Results:
- Post-treatment LW occurred in 23.26% of patients.
- Preoperative LW presence was a significant independent risk factor for post-treatment LW (OR=8.81, p<0.001).
- Preoperative bevacizumab treatment was associated with a reduced risk of LW formation (OR=0.16, p=0.022).
Conclusions:
- CO2 laser surgery combined with T-PDT shows a low incidence of LW formation in RRP treatment.
- Preoperative LW presence is a key predictor of post-treatment LW.
- Bevacizumab may serve as a protective factor against LW development in this context.
Related Concept Videos
01:21Larynx
3.9K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
3.9K
01:19Factors Affecting Pulmonary Ventilation
2.7K
Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
2.7K
01:30Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques
427
Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
427