Mohs Micrographic Surgery in Female Genital Cancers: A Systematic Review

Area of Science:

• Gynecologic Oncology
• Dermatologic Surgery
• Surgical Pathology

Background:

• Mohs micrographic surgery (MMS) shows potential for treating female genital cancers.
• Limited research consolidates clinical outcomes for MMS in this area.
• This review synthesizes recent literature on MMS for female genital malignancies.

Purpose of the Study:

• To evaluate the application and clinical utility of MMS in managing female genital cancers.
• To synthesize current evidence on MMS outcomes for specific genital malignancies.
• To assess the efficacy of MMS in Extramammary Paget’s disease (EMPD), dermatofibrosarcoma protuberans (DFSP), squamous cell carcinoma (SCC), and basal cell carcinoma (BCC).

Main Methods:

• A systematic literature search was performed on PubMed and EMBASE.
• Keywords included "Mohs surgery" and terms related to female genital cancers.
• Studies focused on MMS for EMPD, DFSP, SCC, and BCC with clinical outcome data were included.

Main Results:

• Analysis of 166 treated cases revealed a 95% curative rate with MMS.
• High efficacy was observed for EMPD, DFSP, SCC, and BCC.
• MMS demonstrated significant success in managing these specific female genital cancers.

Conclusions:

• MMS offers superior outcomes to traditional excisional surgery for female genital cancers.
• The precision and histological analysis of MMS contribute to its effectiveness.
• Further research with larger cohorts and diverse malignancies is recommended to refine treatment guidelines.