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Updated: Jan 12, 2026
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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Multimodal therapy process engineering mediated by 3D-printed scaffolds for enhanced postoperative osteosarcoma
Xinyue Liu1, Jie Xu1, Jingjing Zhu1
1Cancer Hospital of Dalian University of Technology, State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, China.
Tissue & Cell
|November 4, 2025
Summary
3D printed scaffolds offer a dual solution for osteosarcoma treatment, aiding bone reconstruction and preventing tumor recurrence through integrated therapies. Future intelligent scaffolds promise improved clinical outcomes.
Area of Science:
- Biomaterials Engineering
- Oncology
- Regenerative Medicine
Background:
- Osteosarcoma resection creates bone defects and risks local recurrence, posing clinical challenges.
- Current treatments struggle to simultaneously address bone regeneration and tumor suppression.
- 3D printed scaffolds offer patient-specific solutions for complex bone defect reconstruction.
Purpose of the Study:
- To review advances in 3D printed scaffolds for synergistic postoperative osteosarcoma management.
- To examine multimodal therapeutic strategies integrated into 3D printed scaffolds.
- To discuss the role of these scaffolds in drug delivery, tumor suppression, and bone regeneration.
Main Methods:
- Comprehensive literature review of 3D printed scaffolds with multimodal therapies.
- Analysis of therapeutic mechanisms including chemotherapy, PTT, MTT, immunotherapy, CDT, and PDT.
- Evaluation of synergistic effects for postoperative osteosarcoma management.
Main Results:
- 3D printed scaffolds can be functionalized with diverse therapies for combined effects.
- Multimodal therapies enhance drug delivery, tumor suppression, and bone regeneration.
- Synergistic approaches show promise for improved osteosarcoma treatment outcomes.
Conclusions:
- 3D printed scaffolds are versatile platforms for multimodal cancer therapy and bone reconstruction.
- Intelligent and personalized scaffolds are key for future clinical translation in osteosarcoma.
- These advanced scaffolds offer a promising strategy for enhanced post-resection management.
