The relationship between high serum UA levels and decidualization and angiogenesis in endometrium

Hyperuricemia (HUA) is the second most common metabolic disease after diabetes and refers to a type of disease in which serum uric acid (SUA) levels are excessively high due to excessive production of uric acid (UA) or reduced metabolic capacity. To elucidate the effect of HUA on angiogenesis in endometrial decidualization, the authors investigated endometrial decidualization markers and angiogenesis factors in the decidua after abortion in women with high uric acid levels and the uterus of mice with high uric acid induced by purines on day 7.5 (D7.5) of gestation. Moreover, immunohistochemical staining was used to measure the diameter of the microvascular lumen and the density of the vessels. Real-time PCR and Western blot results showed that the expressions of prolactin (PRL) and decidua/trophoblast PRL-related protein prolactin family 8, subfamily a, member 2 (Prl8a2) in the decidua of patients with hyperuricemia and the pregnant uterus of high uric acid mice with D7.5 days of gestation were significantly reduced. Additionally, the diameter and density of the microvascular lumen were decreased by immunohistochemical staining of uterine CD34. The expression of vascular endothelial growth factor a (VEGFA) in the endometrium was significantly decreased (P < 0.05). High UA can lead to endometrial decidualization damage and angiogenesis disorders in early pregnancy in humans and mice.