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Updated: Jan 6, 2026

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Directed Dynamic Resolution of an Atropisomeric Silver Complex in Solution: Role of π-π Interactions
Alvaro Polo1, Ricardo Rodríguez1, Pablo J Sanz Miguel1
1Departamento de Química Inorgánica, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), Universidad de Zaragoza-CSIC, 50009 Zaragoza, Spain.
Abstract:
We report a directed dynamic resolution process for an atropisomeric [Ag(NHC)2]+ complex, where stereochemical control is achieved through enantiomeric interconversion in solution before crystallization. Unlike conventional diastereomeric salt formation, our approach shifts the restricted interconversion between Ra and Sa atropisomers, allowing selective stabilization of one enantiomer via π-π interactions with enantiopure binaphthalene-based borate anions in solution. NMR spectroscopy reveals conformational locking and restricted dynamics preceding crystallization, which captures the resolved stereochemistry in highly crystalline salts. This study demonstrates that noncovalent interactions effectively modulate molecular conformational dynamics to achieve chiral resolution.
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