Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.8K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.8K
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

3.3K
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
3.3K
Cell Migration01:19

Cell Migration

6.3K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spin Dewetting of Ultrathin Polymer Films.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Differential regional textural attributes of tongue in normal and acidity patients in the light of traditional Chinese medicine.

Computers in biology and medicine·2026
Same author

<i>In Vivo</i> Drug-Eluting Smart Scaffold for Diabetic Wounds.

ACS applied materials & interfaces·2026
Same author

Human Fidgetin Modulates Cell Migration and EMT in Breast Cancer Cells.

Cell biology international·2025
Same author

Bioengineered Chip Model for Magnetic-Nanoparticle-Driven Targeted Cancer Therapy.

ACS applied materials & interfaces·2025
Same author

Micro-hydrogel molding-assisted fabrication of a PDMS-based microfluidic concentration-gradient generator for dynamic anticancer drug testing.

RSC advances·2025
Same journal

Hemocompatibility of 3D-Printed ABS for Blood-Contacting Applications.

ACS biomaterials science & engineering·2026
Same journal

DNA Origami Microstructures as Biomimetic Scaffolds for Calcium Phosphate Mineralization.

ACS biomaterials science & engineering·2026
Same journal

Multifunctional Silk Fibroin Hydrogel Incorporated with MgFe-Layered Double Hydroxide-Based MOF Composite for Orchestrating Bone Regeneration.

ACS biomaterials science & engineering·2026
Same journal

A DLP-Printed 3D Bioceramplug Fabricated Using a Photocurable Negative Thermo-Responsive Bioceramic Slurry for Cranial Burr-Hole Repair.

ACS biomaterials science & engineering·2026
Same journal

A Microenvironment-Driven Peptide Nanoplatform Enhances Ferroptosis and Antiangiogenic Activity for Triple-Negative Breast Cancer Therapy.

ACS biomaterials science & engineering·2026
Same journal

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
See all related articles

Related Experiment Video

Updated: Jan 12, 2026

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
12:26

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

6.3K

Fibroblast Morphology, Adhesion, and Proliferation over Bio Mimetically Patterned Surfaces.

Ayan Gope1, Anurup Mukhopadhyay2, Jyotirmoy Chatterjee2

  • 1Advanced Technology Development Centre,Indian Institute of Technology, Kharagpur 721302, India.

ACS Biomaterials Science & Engineering
|November 7, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces biomimetic surface topographies, inspired by natural petals, as a chemically inert alternative to traditional methods for guiding cell behavior. Yellow rose petal surfaces enhanced fibroblast adhesion, spreading, and proliferation.

Keywords:
biomimetic replicacellular adhesionfibroblast proliferationhierarchical cuessoft lithography

More Related Videos

Control of Cell Geometry through Infrared Laser Assisted Micropatterning
11:04

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

Published on: July 10, 2021

3.8K
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

4.0K

Related Experiment Videos

Last Updated: Jan 12, 2026

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy
12:26

Control of Cell Adhesion using Hydrogel Patterning Techniques for Applications in Traction Force Microscopy

Published on: January 29, 2022

6.3K
Control of Cell Geometry through Infrared Laser Assisted Micropatterning
11:04

Control of Cell Geometry through Infrared Laser Assisted Micropatterning

Published on: July 10, 2021

3.8K
Fibroblast Derived Human Engineered Connective Tissue for Screening Applications
09:50

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications

Published on: August 20, 2021

4.0K

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Surface Engineering

Background:

  • Traditional surface functionalization for replicating extracellular matrix (ECM) properties often involves chemical modifications, leading to issues like cytotoxicity and poor control.
  • These limitations hinder the application of such materials in long-term and translational biomedical contexts.
  • Exploring physical cues from biomimetic topographies offers a promising alternative.

Purpose of the Study:

  • To investigate the use of material-independent, chemically inert surface topographies inspired by natural geometries to direct cell behavior.
  • To systematically compare the influence of lotus leaf, red rose petal, and yellow rose petal-inspired polydimethylsiloxane (PDMS) topographies on fibroblast responses.
  • To identify specific topographical features that promote desirable cellular interactions for biomedical applications.

Main Methods:

  • Fabrication of high-fidelity PDMS replicas using soft lithography and UV-assisted replication.
  • Characterization of surface topographies using atomic force microscopy (AFM) and scanning electron microscopy (SEM).
  • Assessment of cellular responses including proliferation, morphology, adhesion, spreading, and mechanosensing.

Main Results:

  • Each fabricated surface topography elicited distinct fibroblast-substrate interaction profiles.
  • The yellow rose petal-inspired topography demonstrated superior support for fibroblast adhesion, spreading, and proliferation compared to lotus leaf and red rose petal surfaces.
  • These enhanced cellular responses were correlated with the unique topographical density and orientation of the yellow rose petal surface.

Conclusions:

  • Biomimetic surface topographies can effectively direct cell behavior through physical cues alone, offering a cytocompatible and material-independent approach.
  • Natural geometries, specifically the yellow rose petal topography, provide a valuable blueprint for designing advanced biomaterials.
  • This research presents a novel framework for developing reproducible and effective platforms for regenerative medicine and in vitro biomedical applications.