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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Related Experiment Video

Updated: May 9, 2026

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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In Vivo Drug-Eluting Smart Scaffold for Diabetic Wounds.

Anurup Mukhopadhyay1, Ayan Gope2, Jyotirmoy Chatterjee1,3

  • 1Multimodal Imaging and Theranostics Laboratory, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.

ACS Applied Materials & Interfaces
|May 8, 2026
PubMed
Summary

This study introduces a novel silk fibroin scaffold with bioinspired patterns for enhanced diabetic wound healing. The scaffold accelerates tissue regeneration and overcomes limitations of current treatments.

Keywords:
bioinspired patternsdiabetic wound healingdrug-eluting scaffoldextracellular matrix remodelingmultimodal wound healing evaluationregenerative wound healing

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Published on: August 21, 2021

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Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds
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Doxycycline Loaded Collagen-Chitosan Composite Scaffold for the Accelerated Healing of Diabetic Wounds

Published on: August 21, 2021

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Diabetic wound healing is complex, hindered by hyperglycemia-induced vascular, inflammatory, and immune defects.
  • Existing treatments like hydrogels and skin substitutes have limitations in addressing diabetic wound complexities.

Purpose of the Study:

  • To develop and evaluate a silk fibroin-based scaffold with bioinspired surface patterns for controlled drug delivery.
  • To assess the in vivo efficacy of this scaffold in promoting diabetic wound healing and tissue regeneration.

Main Methods:

  • Fabrication of a silk fibroin scaffold with bioinspired surface patterns for modulated drug release.
  • In vivo evaluation in a diabetic rat model, utilizing Swept-Source Optical Coherence Tomography (SS-OCT), histopathology, and molecular analyses (immunohistochemistry, qPCR).

Main Results:

  • The patterned scaffold significantly accelerated wound healing in diabetic rats.
  • Demonstrated enhanced cellular differentiation, angiogenesis, and extracellular matrix remodeling.
  • SS-OCT, histopathology, and molecular analyses confirmed improved tissue regeneration.

Conclusions:

  • The silk fibroin scaffold effectively integrates structural support with sustained drug release, addressing limitations of current diabetic wound care.
  • This bioinspired approach shows significant potential for clinical translation in managing diabetic wounds.