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Related Experiment Video

Updated: Jun 27, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

Fungal Sinusitis-Invasive Versus Noninvasive.

Christine Franzese¹

¹Department of Otolarynology-Head and Neck Surgery, University of Missouri-Columbia, One Hospital Drive, Suite MA314, Columbia, MO 65212, USA.

The Medical Clinics of North America

|November 8, 2025

Summary

This summary is machine-generated.

Fungal sinusitis, uncommon and diverse, includes noninvasive (SNFB, AFRS) and invasive types. Treatment varies by type and patient immunity, often involving surgery, antifungals, and immune support.

Keywords:

Acute invasive fungal sinusitis Allergic fungal rhinosinusitis Chronic invasive fungal sinusitis Fungal sinusitis Fungus ball

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Area of Science:

Otolaryngology
Mycology
Immunology

Background:

Fungal sinusitis is a rare condition with distinct clinical presentations.
It is broadly classified into noninvasive and invasive forms.
Noninvasive types affect immunocompetent individuals, while invasive forms impact the immunocompromised.

Purpose of the Study:

To outline the classification of fungal sinusitis.
To describe the distinct characteristics and treatment strategies for each type.
To emphasize diagnostic approaches and management principles.

Main Methods:

Literature review of fungal sinusitis classification.
Analysis of clinical presentations of noninvasive and invasive fungal sinusitis.
Summary of current diagnostic imaging and biopsy techniques.
Overview of treatment modalities including surgery, antifungal therapy, and immune management.

Main Results:

Noninvasive forms include sinonasal fungus ball (SNFB) and allergic fungal rhinosinusitis (AFRS).
SNFB typically affects older, immunocompetent patients unilaterally, treated with surgery.
AFRS affects younger patients with fungal hypersensitivity, treated with surgery and medical therapy.
Invasive fungal sinusitis (acute/chronic) affects immunocompromised individuals, requiring urgent intervention.

Conclusions:

Accurate diagnosis via imaging and biopsy is crucial.
Treatment requires a multimodal approach: surgery, antifungals, and immune status management.
Differentiating fungal sinusitis types ensures appropriate and timely patient care.