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Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
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Intracoronary Imaging for Calcium Modification: Intravascular Ultrasound and Optical Coherence Tomography

Doosup Shin1, Sarah Malik1, Mandeep Singh1

  • 1Saint Francis Hospital and Heart Centre Roslyn, New York, US.

Interventional Cardiology (London, England)
|November 10, 2025
PubMed

Insights

Intravascular imaging improves the diagnosis and management of coronary artery calcification (CAC) during percutaneous coronary interventions. This technique helps guide advanced therapies and confirm calcium fracture for better procedural outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Imaging

Background:

  • Coronary artery calcification (CAC) poses significant challenges in percutaneous coronary interventions (PCI), negatively impacting procedural success and long-term results.
  • Traditional angiography has limitations in accurately assessing CAC morphology and severity.
  • Advanced calcium modification therapies are crucial for complex PCI cases involving heavily calcified lesions.

Purpose of the Study:

  • To highlight the role of intravascular imaging in the diagnosis and management of CAC during PCI.
  • To explain how intravascular imaging aids in selecting appropriate calcium modification therapies.
  • To demonstrate the utility of intravascular imaging in confirming calcium fracture and optimizing PCI outcomes.

Main Methods:

  • Comparison of intravascular imaging techniques (e.g., IVUS, OCT) with conventional angiography for CAC assessment.
  • Evaluation of morphological features of CAC identified by intravascular imaging.
  • Assessment of the impact of intravascular imaging-guided calcium modification therapies on PCI outcomes.

Main Results:

  • Intravascular imaging offers superior diagnostic accuracy for CAC compared to angiography.
  • Morphological assessment of CAC using intravascular imaging guides the selection of advanced therapies like atherectomy or intravascular lithotripsy.
  • Intravascular imaging confirms calcium fracture, facilitating successful stent implantation and improving procedural success.

Conclusions:

  • Intravascular imaging is invaluable for accurate CAC diagnosis and characterization in PCI.
  • Utilizing intravascular imaging enables tailored calcium modification strategies, leading to optimized PCI.
  • Understanding and applying intravascular imaging interpretation can significantly improve clinical outcomes in patients undergoing PCI for CAC.

Keywords:
Coronary calcificationintravascular imagingintravascular ultrasoundoptical coherence tomography

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