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β-Glucans in Food Systems: Balancing Health, Safety, and Diabetes Prevention
Xuefeng Liu1, Yuqin Feng1, Yating Song2
1School of Food Science and Engineering, Ningxia University, Yinchuan 750021, China.
Beta-glucans offer a promising avenue for managing type 2 diabetes by modulating gut microbiota and short-chain fatty acid production. This research supports their use in precision nutrition and advanced drug delivery systems.
Area of Science:
- Nutritional Science
- Microbiology
- Pharmacology
Background:
- Type 2 diabetes presents a global health challenge requiring novel therapeutic strategies.
- Conventional treatments for type 2 diabetes have limitations, necessitating safer alternatives.
- Beta-glucans are explored for their potential in diabetes management.
Purpose of the Study:
- To systematically evaluate the potential of beta-glucans in managing type 2 diabetes and its complications.
- To elucidate the mechanisms of action of beta-glucans, including gut microbiota modulation and short-chain fatty acid metabolism.
- To establish scientific intake guidelines and explore beta-glucans' application in precision nutrition and drug delivery.
Main Methods:
- Systematic literature review integrating research on gut microbiota and short-chain fatty acid metabolism.
- Analysis of beta-glucan's impact on metabolic pathways, oxidative stress, and inflammation.
- Safety assessments and investigation of structural stability, functional retention, and nanocarrier properties.
Main Results:
- Beta-glucans remodel microbial metabolic networks via short-chain fatty acid production and bile acid regulation.
- They modulate energy metabolism and disrupt oxidative stress-inflammatory pathways.
- Comprehensive safety data supports guideline establishment and dual application potential.
Conclusions:
- Beta-glucans demonstrate significant potential for type 2 diabetes management through multifaceted mechanisms.
- Their application spans precision nutrition and intelligent nanocarrier-based drug development.
- This research provides a foundation for novel therapeutic and dietary interventions for diabetes.
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