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Updated: Jan 11, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
2-Chloro-4-hy-droxy-anilinium chloride
Sindhu V Bai1, Patrick F Mensah2, Guoqiang Li3
1Department of Environmental Toxicology Southern University and A&M College Baton Rouge Louisiana 70813 USA.
None:
The title compound, C6H7ClNO+·Cl-, crystallizes in ortho-rhom-bic space group Pnma with both cations and anions lying on a mirror plane in the crystal. The C-Cl distance is 1.7289 (6) Å, the C-N distance is 1.4590 (8) Å, and the C-O distance is 1.3617 (8) Å. Parallel mol-ecules form stacks with inter-planar spacing 3.1473 (2) Å, but slipped by 1.97 Å. The NH3 + substituent donates three inter-molecular hydrogen bonds to chloride ions having N⋯Cl distances in the range 3.1514 (6)-3.3019 (2) Å, and the OH group donates an inter-molecular hydrogen bond to chloride with O⋯Cl distance 3.0671 (6) Å. The chloro substituent and OH group do not accept hydrogen bonds from NH or OH.
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