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Electrospinning for Mimicking Bioelectric Microenvironment in Tissue Regeneration.

Zhuowen Hao1,2, Zepu Wang1, Ying Wang3

  • 1Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

Research (Washington, D.C.)
|November 12, 2025
PubMed
Summary

Electrospun scaffolds offer a promising alternative to traditional electrotherapy for tissue regeneration, overcoming issues like patient compliance and infection risks. These advanced materials leverage electrical cues to enhance healing and create bioelectric niches.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Electric signals are crucial for tissue regeneration, with clinical electrotherapy showing effectiveness but facing challenges like invasiveness and infection risk.
  • Electrospun scaffolds present an alternative to invasive electrodes, offering a way to deliver electrical stimulation non-invasively.
  • Understanding the physiological roles of electrical cues and their signaling pathways is key to advancing regenerative therapies.

Purpose of the Study:

  • To review the physiological cues of electric signals in tissue regeneration.
  • To detail fabrication methods for electroactive electrospun scaffolds that mimic the extracellular matrix.
  • To analyze strategies for imparting electroconductivity, piezoelectricity, or triboelectrification to scaffolds for enhanced cell signaling and electrical cue generation.

Main Methods:

  • Review of literature on electrospinning techniques, materials, and fabrication of electroactive scaffolds.
  • Analysis of methods to induce surface potential, electroconductivity, piezoelectricity, and triboelectrification in scaffolds.
  • Summary of smart applications of electroactive electrospun scaffolds in mimicking bioelectric niches.

Main Results:

  • Electrospinning enables the creation of electroactive scaffolds that address limitations of clinical electrotherapy.
  • Various methods exist to imbue scaffolds with electrical properties (e.g., conductivity, piezoelectricity, triboelectrification) for improved cell signaling and regeneration.
  • Smart applications include conductive/piezoelectric scaffolds, composite implants, nanogenerators, and drug delivery systems.

Conclusions:

  • Electroactive electrospun scaffolds show significant potential for mimicking bioelectric niches and promoting tissue regeneration.
  • Further research and development are needed to overcome current challenges for successful clinical translation.
  • These scaffolds offer a promising avenue for developing next-generation regenerative therapies with improved patient outcomes.