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Epigenetic Alterations in Perioperative Anaphylaxis Among Chinese Patients: A Case-Control Study Protocol
Huamei Cai1,2, Zhe Li1,2, Yun Yan1,2
1Department of Anesthesiology China-Japan Friendship Hospital Beijing People's Republic of China.
Health Science Reports
|November 12, 2025
Summary
This study investigates epigenetic changes in Chinese patients experiencing perioperative anaphylaxis (POA), a severe complication. Findings may reveal molecular mechanisms and inform prevention strategies for POA.
Area of Science:
- Anesthesiology
- Immunology
- Epigenetics
Background:
- Perioperative anaphylaxis (POA) is a rare, life-threatening complication.
- Regional incidence differences in China suggest environmental/genetic factors.
- Epigenetic factors are unexplored in POA etiology.
Purpose of the Study:
- To explore epigenetic alterations in Chinese patients with POA.
- To identify epigenetically regulated genes associated with POA.
- To gain insights into POA molecular mechanisms for improved clinical strategies.
Main Methods:
- Case-control study of POA patients and healthy controls.
- Allergen testing (skin tests, basophil activation test) and demographic data collection.
- Whole-genome bisulfite sequencing (WGBS) on PBMCs to detect DNA methylation, analyzed with BSMAP.
Main Results:
- Analysis of differential methylation regions and functional gene pathways between POA patients and controls.
- Identification of potential epigenetic regulators linked to POA.
- Validation of findings within the dataset for robustness.
Conclusions:
- Comprehensive investigation of epigenetic alterations in Chinese POA patients.
- Provides fundamental insights into POA molecular mechanisms.
- Potential to guide future research and inform clinical preventive strategies.
