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Updated: Jan 11, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Transient Hyperphosphatasemia of Infancy and Early Childhood: Two Case Reports
Background:
Transient hyperphosphatasemia of infancy and early childhood (THI) is characterized by a temporary, isolated elevation of serum alkaline phosphatase (ALP) in the absence of hepatic or skeletal pathology. ALP levels may exceed the upper limit of the age-specific reference range by several-fold, while other biochemical and clinical parameters remain normal. Recognition of THI is crucial to avoid unnecessary investigations.
Methods:
Two pediatric cases with markedly elevated ALP were evaluated through laboratory tests, imaging, and clinical follow-up to exclude hepatic or metabolic bone diseases.
Results:
Both cases demonstrated spontaneous normalization of ALP within 2 - 3 months, confirming THI.
Conclusions:
THI is a benign, self-limiting condition requiring no intervention. Increased awareness among clinicians is essential to prevent overdiagnosis and parental anxiety.
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