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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Jan 11, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Contemporary Management of Dermatofibrosarcoma Protuberans.

Lauren M Janczewski¹, Jeffrey D Wayne²

¹Department of Surgery, Northwestern University Feinberg School of Medicine, 676 North St. Clair Street, Arkes Suite 650, Chicago, IL 60611, USA.

Hematology/Oncology Clinics of North America

|November 12, 2025

Summary

This summary is machine-generated.

Dermatofibrosarcoma protuberans, a rare skin sarcoma, presents growth challenges for surgeons. Achieving complete removal is difficult, often leading to recurrence despite various surgical methods.

Keywords:

Dermatofibrosarcoma protuberans Immunotherapy Mohs surgery Multidisciplinary care Radiotherapy Surveillance Wide local excision

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Area of Science:

Oncology
Surgical Pathology

Background:

Dermatofibrosarcoma protuberans is a rare, low-grade skin sarcoma.
It is characterized by tentacle-like extensions into subcutaneous tissue.
These features make complete surgical resection challenging.

Purpose of the Study:

To review the challenges in treating dermatofibrosarcoma protuberans.
To discuss current surgical approaches for this rare sarcoma.

Main Methods:

Literature review of dermatofibrosarcoma protuberans treatment.
Analysis of surgical techniques including wide local excision, Mohs micrographic surgery, and multidisciplinary approaches.

Main Results:

Surgical resection is the primary treatment for dermatofibrosarcoma protuberans.
Achieving negative margins is difficult due to irregular tumor growth.
High local recurrence rates are associated with incomplete resection.

Conclusions:

Effective management of dermatofibrosarcoma protuberans requires addressing its infiltrative growth.
Various surgical strategies exist, each with implications for local control and recurrence.