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Related Concept Videos

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Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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Corrigendum to "Effect of degree of substitution of octenyl succinate on starch micelles for synthesis and stability of selenium nanoparticles: Towards selenium supplements" [Int. J. Biol. Macromol. 280 (2024) 135586].

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Recent Advances Towards Selenium Nanoparticles: Synthetic Methods, Functional Mechanisms, and Biological

Lulu Geng1,2, Linling Li2, Xuening Sun1,2

  • 1National R&D Center for Se-rich Agricultural Products Processing, Wuhan Polytechnic University, Wuhan 430023, China.

Foods (Basel, Switzerland)
|November 13, 2025
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Summary

This review compares synthesis methods for selenium nanoparticles (SeNPs), highlighting how shape and size control efficacy. It also discusses SeNPs

Keywords:
biological applicationfunctional mechanismselenium nanoparticlesynthetic method

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Area of Science:

  • Nanotechnology and Materials Science
  • Biomedical Engineering
  • Pharmacology

Background:

  • Selenium nanoparticles (SeNPs) exhibit unique physicochemical properties driving their development.
  • SeNP functionality is critically dependent on particle size and morphology.
  • Synthesis methods dictate SeNP characteristics, influencing their biological applications.

Purpose of the Study:

  • To critically analyze and compare physical, chemical, and biosynthetic SeNP synthesis methods.
  • To elucidate the relationship between synthesis parameters, SeNP properties (size, shape, stability), and functional efficacy.
  • To review the mechanisms underlying SeNP's anti-tumor, antioxidant, and antibacterial activities.

Main Methods:

  • Comparative analysis of established physical, chemical, and biosynthetic SeNP synthesis techniques.
  • Review of literature focusing on the characterization and property-function relationships of SeNPs.
  • Elucidation of SeNP biological activities through mechanistic insights from existing studies.

Main Results:

  • Different synthesis methods offer varying degrees of control over SeNP size, morphology, and stability.
  • Standardized characterization protocols are essential for reliable comparison of SeNP studies.
  • SeNPs demonstrate significant potential in anti-tumor, antioxidant, and antibacterial applications.

Conclusions:

  • A systematic link between SeNP synthesis, properties, functions, and applications is established.
  • Challenges to clinical and commercial translation include standardization of toxicological evaluation, scalable synthesis, and regulatory hurdles.
  • Further research is needed to optimize SeNP synthesis for targeted therapeutic applications and overcome translational barriers.