Nutritional Approaches in Neurodegenerative Disorders: A Mini Scoping Review with Emphasis on SPG11-Related...

Area of Science:

• Neuroscience
• Metabolic Disorders
• Nutritional Science

Background:

• Spastic paraplegia type 11 (SPG11) is a neurodegenerative disease linked to impaired spatacsin function, affecting autophagy and lysosomal homeostasis.
• Neuronal dysfunction in SPG11 results from defective cellular clearance, leading to progressive neurological decline.
• Personalized and precision nutrition offer tailored dietary interventions based on individual profiles to improve health outcomes.

Purpose of the Study:

• To review current evidence on personalized nutrition applications in SPG11.
• To explore how insights from other neurodegenerative diseases can inform SPG11 dietary interventions.

Main Methods:

• A mini scoping review adhering to PRISMA-ScR guidelines.
• Searched PubMed, Scopus, and Web of Science databases from 2020-2024.
• Included studies on nutritional, genomic, or metabolic interventions in neurodegenerative diseases.

Main Results:

• No dietary intervention trials have been specifically conducted for SPG11 to date.
• Studies in related neurodegenerative diseases indicate potential benefits from antioxidant, mitochondrial-supportive, and microbiota-targeted diets.
• These dietary approaches may positively impact oxidative stress, lipid dysregulation, and autophagy, key in SPG11.

Conclusions:

• Personalized nutrition is a promising adjunctive strategy for managing SPG11, despite preliminary evidence.
• Future research should integrate systems-based approaches, including dietary, metabolic, and neuroimaging assessments.
• Stratified analyses (sex, comorbidities), multi-omics, and predictive modeling are crucial for developing effective, personalized nutritional interventions for SPG11.