Single-case study of a secondary interdigitating dendritic cells sarcoma highlights the role of RAS mutation in trans-differentiation phenomenon and uncovers a potential efficacy of anti-CD19 CAR-T cell therapy

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...