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Brain hacks: Engineering a microbial factory for Parkinson's disease
1Department of Neurology, National Taiwan University Hospital, Taipei 100225, Taiwan; Institute of Molecular Medicine and Institute of Biomedical Engineering, College of Medicine, National Taiwan University, Taipei 100233, Taiwan.
Abstract:
Motor complications in Parkinson's disease (PD) are exacerbated by the pulsatile delivery of levodopa (L-DOPA). In this issue of Cell Host & Microbe, Padhi et al. engineer a microbiota-based therapeutic for sustained, non-fluctuating L-DOPA production, demonstrating therapeutic promise through stable dopamine signaling.
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