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Magnetic Resonance Imaging01:24

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Normothermic Ex Vivo Liver Machine Perfusion in Mouse
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Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.

Gregory Simchick1, James Rice2, Leah M Gober3

  • 1Radiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Magnetic Resonance in Medicine
|November 14, 2025
PubMed
Summary
This summary is machine-generated.

Perfused explanted human livers can validate intravoxel incoherent motion (IVIM) techniques. This study shows IVIM parameters correlate with liver fibrosis, suggesting potential for clinical application in assessing liver disease.

Keywords:
abdomendeceaseddiffusion weighted imagingdonorex vivointravoxel incoherent motionliverquantitative magnetic resonance imaging

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Hepatology

Background:

  • Intravoxel incoherent motion (IVIM) is a quantitative MRI technique used to assess tissue microcirculation.
  • Validating IVIM parameters in biologically accurate systems is crucial for its clinical translation.
  • Explanted human livers offer a unique model for studying liver physiology and disease under controlled conditions.

Purpose of the Study:

  • To evaluate the feasibility of using perfused explanted human livers for validating IVIM parameters.
  • To investigate the relationship between IVIM parameters and liver fibrosis stages in an ex vivo model.

Main Methods:

  • Eight human explanted livers were perfused, and IVIM data were acquired at varying flow rates (0-1.2 L/min).
  • Key IVIM parameters, including diffusion coefficient (D), perfusion fraction (Fc), and blood velocity (Vb/D*), were estimated.
  • Linear mixed-effects modeling analyzed the effects of flow rate and fibrosis stage on IVIM parameters.

Main Results:

  • Diffusion coefficient (D) was independent of flow rate. Perfusion fraction (Fc) was non-zero with applied flow and independent of flow rate.
  • Blood velocity parameters (Vb and D*) were dependent on applied flow and flow rate.
  • Moderate-to-advanced fibrosis (F2-4) showed significantly lower Fc, Vb, and D* estimates compared to no-to-mild fibrosis (F0-1).

Conclusions:

  • Perfused explanted human livers provide a biologically relevant system for validating quantitative IVIM MRI techniques.
  • IVIM parameter changes correlate with liver fibrosis severity, indicating potential for non-invasive assessment of liver disease.