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Management of Pediatric Intestinal Failure

Batul Kaj-Carbaidwala1, Corie M Klepper1, Danielle Wendel2

  • 1Division of Gastroenterology, Hepatology and Nutrition, Ann and Robert H Lurie Children's Hospital of Chicago, 225 East Chicago Avenue, Chicago, IL, USA.

Gastroenterology Clinics of North America
|November 14, 2025
PubMed

Insights

Pediatric intestinal failure (IF) management has improved significantly, offering better survival and outcomes. Intestinal rehabilitation programs aim to achieve enteral autonomy, reducing reliance on parenteral nutrition.

Area of Science:

  • Pediatric gastroenterology and nutrition
  • Intestinal rehabilitation
  • Parenteral nutrition management

Background:

  • Pediatric intestinal failure (IF) management has seen significant advancements over the past two decades.
  • Historically associated with high morbidity and mortality, IF is now a diagnosis with improved survival and long-term outcomes.
  • The primary objective in managing IF is to achieve enteral autonomy.

Purpose of the Study:

  • To describe the epidemiology and definitions of pediatric IF.
  • To highlight the critical role of specialized intestinal rehabilitation programs.
  • To provide an overview of current management strategies, focusing on medical interventions and complication prevention/treatment.

Main Methods:

  • Review of epidemiological data and definitions related to pediatric IF.
  • Analysis of the components and outcomes of intestinal rehabilitation programs.
  • Synthesis of medical management strategies, including nutritional support and complication management.

Main Results:

  • Significant improvements in survival rates and long-term outcomes for pediatric IF patients.
  • Demonstrated effectiveness of intestinal rehabilitation programs in achieving enteral autonomy.
  • Established protocols for medical management, focusing on preventing and treating IF-related complications.

Conclusions:

  • Pediatric intestinal failure is now a manageable condition with a positive prognosis.
  • Intestinal rehabilitation programs are essential for achieving enteral autonomy and improving patient quality of life.
  • Comprehensive medical management, including complication care, is key to successful long-term outcomes in pediatric IF.

Keywords:
Intestinal failureParenteral nutritionShort bowel syndrome

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