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Platelet Gene Expression in Systemic Lupus Erythematosus and Cardiovascular Health

Matthew A Muller1, Elliot Luttrell-Williams2, Hannah Bash3

  • 1Division of Precision Medicine, Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA; Institute of Systems Genetics, Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA; Department of Biomedical Engineering, New York University Tandon School of Engineering, New York, New York, USA.

JACC. Basic to Translational Science
|November 15, 2025
PubMed

Insights

The Systemic Lupus Erythematosus Activity Platelet-Gene Expression Signature (SLAP-GES) score reflects disease activity and is linked to heightened platelet activity and poorer vascular health in lupus patients.

Area of Science:

  • Immunology
  • Cardiovascular Medicine
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is an autoimmune disease associated with increased cardiovascular risks.
  • Vascular dysfunction is a significant concern in SLE patients.
  • Existing biomarkers may not fully capture the complexity of SLE's impact on vascular health.

Purpose of the Study:

  • To validate the Systemic Lupus Erythematosus Activity Platelet-Gene Expression Signature (SLAP-GES) score.
  • To assess the relationship between SLAP-GES, platelet activity, and vascular health markers in SLE.

Main Methods:

  • Validation of the SLAP-GES score against established SLE disease activity metrics.
  • Assessment of platelet aggregation, leukocyte-platelet aggregates, and neutrophil-platelet aggregates.
  • Evaluation of glycocalyx integrity and brachial artery flow-mediated dilation.

Main Results:

  • SLAP-GES demonstrated consistency over time and strong association with SLE disease activity.
  • Elevated SLAP-GES correlated with increased platelet aggregation and circulating platelet-leukocyte/neutrophil aggregates.
  • SLAP-GES was significantly associated with impaired glycocalyx and reduced flow-mediated dilation.

Conclusions:

  • The SLAP-GES score is a validated measure of SLE disease activity.
  • SLAP-GES is a potential indicator of heightened platelet activity in SLE.
  • SLAP-GES is associated with vascular dysfunction, including impaired glycocalyx and endothelial function, in SLE patients.

Keywords:
SLEplateletstranscriptomevascular health

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