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Medical Management of Rhinitis: Medication Options.
Sylvia Li1, Marcus Shaker2, Anju Peters1
1Division of Allergy and Immunology, Northwestern Feinberg School of Medicine, 211 E Ontario Street, Suite 1000, Chicago, IL 60611, USA.
Immunology and Allergy Clinics of North America
|November 15, 2025
Summary
Pharmacologic rhinitis treatments, including intranasal corticosteroids and oral antihistamines, offer effective symptom relief. Emerging therapies show promise for managing allergic rhinitis and inflammation.
Area of Science:
- Allergy and Immunology
- Pharmacology
Background:
- Rhinitis management involves various intranasal and oral pharmacologic agents.
- Current treatments target inflammation and histamine pathways for symptom control.
Purpose of the Study:
- To review current pharmacologic treatments for rhinitis.
- To discuss the efficacy, safety, and emerging therapies for rhinitis.
Main Methods:
- Literature review of intranasal and oral rhinitis medications.
- Analysis of clinical and preclinical data on emerging therapies.
Main Results:
- Intranasal corticosteroids and non-sedating antihistamines are first-line treatments.
- Various oral medications provide symptom-specific relief with differing side effect profiles.
- Biologics and CRTH2/DPP-4 inhibitors demonstrate potential in ongoing research.
Conclusions:
- Pharmacologic rhinitis treatment encompasses a range of options from established first-line agents to novel therapies.
- Individualized treatment selection is crucial based on efficacy, safety, and specific rhinitis symptoms.
- Future research directions include further investigation of emerging biologic and targeted pathway inhibitors.
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