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Inflammatory biomarkers in pericarditis: a comprehensive clinical review
Bülent Özlek1, Veysel Ozan Tanık2, Süleyman Barutçu1
1School of Medicine, Department of Cardiology, Muğla Sıtkı Koçman University, Muğla, Turkey.
Biomarkers in Medicine
|November 17, 2025
Summary
C-reactive protein is a key biomarker for diagnosing and monitoring pericarditis, though its utility is limited. Future pericarditis management will integrate biomarkers with imaging and AI for personalized treatment.
Area of Science:
- Cardiology
- Biomarker Research
- Inflammatory Diseases
Background:
- Inflammatory biomarkers are crucial for pericarditis diagnosis, risk stratification, and treatment monitoring.
- Current biomarkers face limitations including non-specificity, variability, and treatment interactions.
Purpose of the Study:
- To review current evidence and guidelines on conventional and emerging biomarkers for pericarditis.
- To explore the role of biomarkers in acute, recurrent, and chronic pericarditis.
Main Methods:
- Narrative review of recent studies and 2025 ESC/ACC guidelines.
- Focus on conventional (CRP, troponin, ESR, WBC) and emerging biomarkers.
- Integration of biomarker data with imaging findings, particularly cardiac MRI.
Main Results:
- C-reactive protein (CRP) is the most practical biomarker for diagnosis and monitoring, with elevated levels indicating recurrence risk.
- Troponin aids in identifying myocardial involvement but doesn't impact outcomes in idiopathic cases.
- Emerging biomarkers show potential but require further standardization and accessibility.
Conclusions:
- Biomarkers are central but imperfect in pericarditis management.
- Future directions include integrating biomarkers with imaging, composite panels, and AI for precision medicine.
- Current practice relies on a combined clinical, laboratory, and imaging assessment.
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