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Updated: Jan 11, 2026
A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Pd-Catalyzed Hydroxylation of Aryl Halides under Air and in Eco-Friendly Solvent
Gwendolyn A Jones1, Mariam Beshara1, Jacob E Levin1
1Department of Chemistry, Lake Forest College, 555 N. Sheridan Road, Lake Forest, Illinois 60045, United States.
Abstract:
A Pd-catalyzed synthesis of phenols in 10% aqueous poly-(ethylene glycol)-2000 (PEG) under an air atmosphere is reported. The reaction proceeds with NaOH as opposed to other BippyPhos/Pd systems in organic solvents that rely on more expensive and reactive CsOH. The reported method converts aryl chlorides, bromides, and iodides with a variety of functional groups at 90 °C to the corresponding phenols in moderate to excellent yields. Due to the aerobic atmosphere, these conditions also oxidize benzyl alcohol substituents to the corresponding aldehyde.
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