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Cinematic Rendering of Bone SPECT/CT.

Martin W Huellner1, Klaus Engel2, Harald Essig3

  • 1Department of Nuclear Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Clinical Nuclear Medicine
|November 19, 2025
PubMed
Summary
This summary is machine-generated.

[99mTc]Tc-DPD-SPECT/CT imaging successfully diagnosed hemimandibular hyperplasia in a young patient. This nuclear medicine technique ruled out fibrous dysplasia and visualized mandibular asymmetry and increased bone turnover.

Keywords:
bone and bonescomputer-assistedemission-computedgrowth disordershyperplasiaimage processingjawnuclear medicinesingle-photontomography

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Area of Science:

  • Nuclear Medicine
  • Radiopharmaceuticals
  • Medical Imaging

Background:

  • Facial asymmetry can stem from various conditions, including fibrous dysplasia and hemimandibular hyperplasia.
  • Accurate diagnosis is crucial for appropriate management of craniofacial abnormalities.

Purpose of the Study:

  • To evaluate the utility of [99mTc]Tc-DPD-SPECT/CT in diagnosing the cause of facial asymmetry in a pediatric patient.
  • To differentiate between fibrous dysplasia and hemimandibular hyperplasia using advanced imaging.

Main Methods:

  • A 14-year-old boy with facial asymmetry underwent [99mTc]Tc-DPD-SPECT/CT of the jaw.
  • Bone biopsy was performed for histological examination.
  • Cinematic rendering was utilized for enhanced visualization of imaging data.

Main Results:

  • [99mTc]Tc-DPD-SPECT/CT ruled out fibrous dysplasia.
  • The imaging confirmed hemimandibular hyperplasia as the cause of asymmetry.
  • Cinematic rendering effectively demonstrated mandibular and dental asymmetry, along with increased condylar bone turnover.

Conclusions:

  • [99mTc]Tc-DPD-SPECT/CT is a valuable tool for diagnosing hemimandibular hyperplasia.
  • This imaging modality can effectively differentiate from other bone pathologies like fibrous dysplasia.
  • Advanced visualization techniques like cinematic rendering improve the understanding of craniofacial abnormalities.