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A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
Published on: September 20, 2019
Update on Neoadjuvant and Adjuvant Trials
Raphael S Werner1, Nina Steinmann1, Isabelle Opitz2
1Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
Abstract:
Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer mortality worldwide. Recent advances incorporate immune checkpoint inhibitors with chemotherapy in neoadjuvant and perioperative settings, significantly improving pathologic response and survival outcomes. Landmark phase III trials demonstrate increased complete response rates and prolonged event-free and overall survival, especially in programmed death-ligand 1 (PD-L1)-positive tumors. Ongoing studies aim to optimize treatment duration, assess the role of adjuvant immunotherapy, and explore biomarkers like circulating tumor DNA for personalized therapy and de-escalation. These developments are transforming the management of locally advanced NSCLC, but further research is required to refine patient selection, tailor treatment intensity and develop predictive biomarkers for a personalized care.
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