Related Experiment Video
Updated: Jan 10, 2026
08:54
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
14.4K
Emerging Biomarkers for Managing Barrett's Esophagus
Pakdee Rojanasopondist1, Andrew Kaz2, Ming Yu3
1Department of Internal Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356421, Seattle, WA 98195-6421, USA.
Gastrointestinal Endoscopy Clinics of North America
|November 19, 2025
Summary
Molecular alterations in esophageal tissue offer promising biomarkers for Barrett
Area of Science:
- Molecular pathology and biomarker discovery in gastrointestinal diseases.
Background:
- Barrett's Esophagus (BE) and esophageal adenocarcinoma exhibit distinct molecular changes.
- Identifying reliable biomarkers is crucial for managing BE and predicting cancer risk.
Purpose of the Study:
- To review and highlight promising molecular biomarkers for esophageal diseases, particularly BE.
- To assess the current status and future potential of various biomarker types.
Main Methods:
- Comparative analysis of molecular profiles (DNA, epigenetics, RNA, proteins) in normal, BE, and adenocarcinoma tissues.
- Review of established and emerging biomarker technologies for esophageal diagnostics.
Main Results:
- Multi-target esophageal cytology DNA assays (methylated-DNA) and Trefoil factor 3 immunohistochemistry are promising for BE management.
- MicroRNA, genomic instability measures, and novel biomarkers (VOCs, saliva microbiome) show potential but require further validation.
Conclusions:
- Distinct molecular signatures in esophageal tissues can serve as valuable disease-specific biomarkers.
- Established biomarkers show clinical promise, while novel approaches need extensive prospective validation for clinical utility.
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