Innovations in Nonendoscopic Screening in Barrett's Esophagus

The goal of this review is to describe data for nonendoscopic screening techniques for the detection of Barrett's esophagus (BE). Endoscopic screening is currently the primary modality for BE detection. A more effective strategy could use risk-based models that integrate clinical factors and are embedded in electronic health records to guide screening. High-risk patients may need endoscopy, while low-risk patients could benefit from less invasive tools like cell collection devices with biomarkers. Integrating BE screening into primary care will be critical in improving early detection of esophageal adenocarcinoma.