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Related Experiment Video

Updated: May 2, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Adaptive radiotherapy for gastrointestinal malignancies.

Joshua P Schiff¹, Beatriz Guevara², Amir Ahari¹

¹Department of Radiation Oncology, Keck School of Medicine of USC, Los Angeles, CA, USA.

Radiation Oncology (London, England)

|November 20, 2025

Summary

Adaptive radiotherapy (ART) adjusts treatment plans for gastrointestinal (GI) cancers based on anatomical changes. This approach is crucial for managing GI malignancies and reducing treatment toxicity.

Keywords:

Adaptive radiotherapy Anal cancer Cholangiocarcinoma Gastrointestinal malignancies Hepatocellular carcinoma Image-guided radiotherapy Pancreatic cancer Rectal cancer

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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

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Area of Science:

Radiation Oncology
Medical Physics
Gastrointestinal Oncology

Background:

Adaptive radiotherapy (ART) is an advanced image-guided radiotherapy technique.
ART involves re-planning treatments to account for changes in patient anatomy during therapy.
This is particularly critical for gastrointestinal (GI) cancers due to the mobile and radiosensitive nature of the GI tract.

Purpose of the Study:

To review the indications for online and offline adaptive radiotherapy in GI cancers.
To highlight the role of ART in managing GI malignancies and reducing toxicity.

Main Methods:

Review of online and offline ART workflows in GI cancer treatment.
Discussion of ART applications in pancreatic, liver, anal, and rectal cancers.
Exploration of stereotactic body radiotherapy (SBRT) applications with ART.

Main Results:

ART allows for safe dose-escalated treatment of locally advanced pancreatic cancer using SBRT.
ART facilitates safe single-fraction abdominal SBRT for liver cancers and abdominal oligometastases.
Both online and offline ART workflows show potential for reducing toxicity in anal and rectal cancers.

Conclusions:

ART is an expanding radiotherapy paradigm successfully incorporated into various GI cancer treatments.
ART workflows in pancreatic, liver, and lower GI cancers are being integrated into multi-center trials.
ART is predicted to play a critical role in the management of GI malignancies with increasing global adoption and efficiency improvements.