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Published on: January 27, 2014
Isoquinoline Alkaloids From Fibraurea recisa With Anti-acetylcholinesterase Activity
Kai Zhao1, Qian-Yi Situ1, Miao Wang1
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research College of Pharmacy, Jinan University, Guangzhou, P. R. China.
Abstract:
Two new 8-oxoprotoberberine alkaloids (1 and 2), one new isoquinoline alkaloid (8), and a pair of enantiomeric isoindolebenzazepine alkaloids (10a and 10b) were isolated from the vine stems of Fibraurea recisa Pierre. Their structures and absolute configurations were elucidated by spectroscopic methods (mass spectrometry, ultraviolet, infrared, one- and two-dimensional nuclear magnetic resonance), quantum chemical electronic circular dichroism calculations, and single-crystal X-ray crystallography. All isolated compounds were evaluated for acetylcholinesterase inhibitory activity, with compound 4 exhibiting significant inhibition.
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