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Epigenetic Therapeutics in Human Heart Failure.
Steven Leon1, Chia-Feng Liu2, W H Wilson Tang3
1Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Cleveland, OH, USA.
Heart Failure Clinics
|November 20, 2025
Summary
Epigenetics plays a crucial role in heart failure (HF) development. Novel epigenetic medications are emerging as a promising therapeutic strategy for treating this widespread cardiovascular condition.
Area of Science:
- Cardiology
- Molecular Biology
- Pharmacology
Background:
- Heart failure (HF) is a global health burden affecting systolic and/or diastolic heart function.
- Rising HF prevalence necessitates innovative treatment strategies.
- Epigenetic mechanisms are increasingly recognized in HF pathogenesis.
Purpose of the Study:
- To review emerging epigenetic-based medications for HF treatment.
- To highlight the therapeutic potential of novel epigenetic drugs.
Main Methods:
- Literature review of current clinical development of epigenetic therapies for HF.
- Summary of key findings from preclinical and clinical studies.
Main Results:
- Several epigenetic modifications are implicated in HF.
- Epigenetic drugs targeting these modifications show promise in early development.
- This novel drug class offers a new avenue for HF management.
Conclusions:
- Epigenetic dysregulation is a significant factor in HF.
- Targeting epigenetic mechanisms represents a promising therapeutic frontier for HF.
- Further research and clinical trials are essential to validate these novel treatments.
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