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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Cardiomyopathy V: Interprofessional Care01:29

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Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
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Cardiomyopathy I: Introduction and Classification01:25

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Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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Epigenetic Regulation in Dilated Cardiomyopathy.

Chia-Feng Liu1, Steven Leon2, W H Wilson Tang3

  • 1Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic Research, Cleveland Clinic, Mail code NC10, Cleveland, OH 44195, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA.

Heart Failure Clinics
|November 20, 2025
PubMed
Summary
This summary is machine-generated.

Dilated cardiomyopathy (DCM) involves genetic and environmental factors. Epigenetic mechanisms like DNA methylation and noncoding RNAs are key to understanding DCM pathogenesis and developing new treatments.

Keywords:
Diabetic cardiomyopathy autoimmune DCMDilated cardiomyopathyEpigeneticLMNA

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Area of Science:

  • Cardiology
  • Genetics
  • Epigenetics

Background:

  • Dilated cardiomyopathy (DCM) is a heart muscle disease causing impaired contractility and heart failure.
  • DCM has diverse causes, including genetic predispositions and environmental factors.
  • Epigenetic mechanisms are increasingly recognized as crucial in DCM development.

Purpose of the Study:

  • To explore the role of epigenetic mechanisms in the pathogenesis of dilated cardiomyopathy.
  • To review familial and non-genetic forms of DCM, highlighting genetic and environmental links.
  • To identify potential biomarkers and therapeutic targets for DCM management.

Main Methods:

  • Review of recent scientific literature on DCM and epigenetics.
  • Analysis of familial DCM associated with gene variants (e.g., lamin A/C, titin).
  • Examination of non-genetic DCM forms (e.g., diabetic, autoimmune).

Main Results:

  • Epigenetic factors, including DNA methylation, histone modifications, and noncoding RNAs, significantly regulate gene expression in DCM.
  • Pathogenic variants in genes like lamin A/C and titin are linked to familial DCM.
  • Environmental factors contribute to DCM, interacting with genetic predispositions via epigenetic pathways.

Conclusions:

  • Epigenetic mechanisms serve as a critical link between genetic and environmental influences in DCM.
  • Understanding these epigenetic factors offers potential for novel diagnostic biomarkers.
  • Targeting epigenetic pathways presents promising therapeutic strategies for DCM.