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Updated: Jan 10, 2026

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
Liver Failure from Alcohol Takes on Several Forms: Decompensated Cirrhosis, Acute-on-Chronic Liver Failure, and
1Division of Digestive and Liver Diseases, Center for Liver Disease and Transplantation, Columbia University, 622 West 168th Street, PH 14, New York, NY 10032, USA. Electronic address: https://twitter.com/geneyim.
Abstract:
Liver failure from alcohol can take on several forms, including decompensated alcohol-related cirrhosis (AC), acute-on-chronic liver failure (ACLF), and alcohol-related hepatitis (AH). While the definitions of decompensated AC and AH are well-established concepts in alcohol-related liver disease (ALD), ACLF is a contemporary and controversial concept of a severe form of acutely decompensated cirrhosis characterized by the existence of organ system failure(s) and a high risk of short-term mortality. While these terminologies have overlapping features, they are distinct and useful by capturing the varied clinical phenotypes within the spectrum of life-threatening ALD.
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