Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Antinuclear antibody (ANA) screening based on EULAR/ACR 2019 clinical domain criteria among PLHIV and profile of diagnosed HIV-SLE cases.

AIDS research and therapy·2026

Same author

Severe visceral leishmaniasis in Ethiopia: Outcomes, co-infections and mortality in a prospective real-world cohort.

PLoS neglected tropical diseases·2026

Same author

Prognostic models predicting clinical outcomes in patients diagnosed with visceral leishmaniasis: a systematic review.

BMJ public health·2026

Same author

Visceral leishmaniasis elimination in South Asia: lessons learnt can inform disease elimination in East Africa.

BMJ global health·2026

Same author

Skin pharmacokinetics and pharmacodynamics in patients with post-kala-azar dermal leishmaniasis.

International journal of antimicrobial agents·2026

Same author

The development of a global research agenda and individual participant data platform for visceral leishmaniasis: challenges and future opportunities.

Parasites & vectors·2025

Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026

Same journal

Accidental hypothermia.

Nature reviews. Disease primers·2026

Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026

Same journal

Primary aldosteronism.

Nature reviews. Disease primers·2026

Same journal

Buruli ulcer in Africa: between innovation and pragmatism.

Nature reviews. Disease primers·2026

Same journal

Author Correction: Atopic dermatitis.

Nature reviews. Disease primers·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 10, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

Leishmaniasis.

Myrthe Pareyn¹, Fabiana Alves², Sakib Burza^3,4

¹Clinical Sciences Department, Institute of Tropical Medicine, Antwerp, Belgium.

Nature Reviews. Disease Primers

|November 20, 2025

Summary

This summary is machine-generated.

Leishmaniasis, a parasitic disease transmitted by sandflies, presents as severe visceral or skin-affecting cutaneous forms. Control efforts focus on improved diagnostics, treatments, and vector control for elimination.

More Related Videos

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

Published on: April 4, 2025

Related Experiment Videos

Last Updated: Jan 10, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

Published on: April 21, 2012

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice

Published on: February 20, 2020

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

In Vivo Imaging of Leishmania infantum-infected Hamsters by Gingival Inoculation of Axenic Amastigotes Expressing Luciferase

Published on: April 4, 2025

Area of Science:

Tropical medicine
Parasitology
Public health

Background:

Leishmaniasis is a significant neglected tropical disease caused by Leishmania parasites and transmitted by sandflies.
It manifests as visceral leishmaniasis (VL) or cutaneous leishmaniasis (CL), with varying severity influenced by parasite, host, and vector factors.
Current diagnostics include the rK39 test for VL and microscopy for CL, with treatment varying by disease form.

Purpose of the Study:

To provide an overview of leishmaniasis, including its transmission, clinical manifestations, and diagnostic methods.
To highlight current treatment strategies for both visceral and cutaneous leishmaniasis.
To discuss the World Health Organization's roadmap for leishmaniasis control and elimination and regional progress.

Main Methods:

Literature review and synthesis of existing data on leishmaniasis epidemiology, clinical presentation, diagnosis, and treatment.
Analysis of global and regional control initiatives, including the WHO 2021-2030 roadmap.
Summary of challenges and future directions for leishmaniasis elimination.

Main Results:

Leishmaniasis affects multiple continents, with distinct forms (VL and CL) and complex disease determinants.
Diagnostic tools like rK39 and microscopy are crucial, alongside varied treatment approaches from systemic to topical therapies.
Significant regional programs in South Asia and Eastern Africa show promise, but sustained progress requires multifaceted interventions.

Conclusions:

Eliminating visceral leishmaniasis and controlling cutaneous leishmaniasis are key global health goals.
Sustainable leishmaniasis control necessitates advancements in diagnostics, treatments, vector control, surveillance, and political commitment.
Vaccine development remains a critical area for future progress in combating leishmaniasis.