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Differences in Resting-State Functional Connectivity of Temperament-Based Profiles Among Youths With
Jaden A Sangoi1, Michael B Kozlowski2, Kathleen E Feeney1
1Department of Psychology, Florida International University.
Temperament profiles may explain biological differences in attention-deficit/hyperactivity disorder (ADHD). Surgent youths showed distinct amygdala-network connectivity compared to typically developing peers, suggesting a basis for further ADHD research.
Area of Science:
- Neuroscience
- Psychiatry
- Developmental Psychology
Background:
- The fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria do not fully capture the heterogeneity of attention-deficit/hyperactivity disorder (ADHD).
- Temperament profiles offer a potential framework for understanding biological heterogeneity within ADHD.
- Previous research identified distinct temperament profiles in youths with ADHD, linked to unique resting-state functional connectivity patterns.
Purpose of the Study:
- To replicate and validate resting-state functional connectivity patterns associated with two previously identified temperament profiles in youths with ADHD.
- To investigate differences in functional connectivity between amygdala and 12 Gordon networks among ADHD temperament profiles and typically developing (TD) youths.
Main Methods:
- Comparison of resting-state functional connectivity between bilateral amygdalae and 12 Gordon networks.
- Analysis included youths with ADHD categorized into two temperament profiles (Surgent and Irritable) and a typically developing (TD) control group.
- Statistical analysis utilized beta coefficients (β) to quantify connectivity strength.
Main Results:
- Surgent youths exhibited significantly stronger right amygdala-dorsal attention network connectivity (β = 0.0434) compared to TD youths.
- Surgent youths also showed stronger right amygdala-retrosplenial temporal network connectivity (β = 0.0442) relative to TD youths.
- Irritable youths displayed unique connectivity patterns compared to both TD and surgent groups, but these findings did not reach statistical significance after correction for multiple comparisons.
Conclusions:
- Findings support the utility of temperament profiles in explaining biological heterogeneity in ADHD.
- The study highlights specific amygdala-network connectivity differences in surgent ADHD youths, warranting further investigation.
- Future research should continue exploring temperament-based stratification for a more nuanced understanding of ADHD.
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